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Treatment of melasma by low-fluence 1064 nm Q-switched Nd:YAG laser

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Release Time：2023-08-21 14:19

Treatment of melasma by low-fluence 1064 nm Q-switched Nd:YAG laser


Melasma is a common pigmentation lesion of the skin and it 
predominantly affects women with darker complexions. Among 
various etiologic factors including genetic predisposition and 
hormonal influences, exposure to UV light plays key role in 
pathogenesis of melasma. 
Low-fluence 1064 nm Q-switched Nd:YAG laser is 
an effective method to treat melasma without serious side 
effects in Asian patients.
   Fifty patients with melasma underwent 15 weeks of weekly 
treatments, using a Q-switched Nd:YAG laser at 1064 nm with an 8-mm spot size, and a fluence of 2.8 J/cm2 . Patients and investigators 
subjectively evaluated the intensity of pigmentation after 
completion of 15 weekly treatments. The objective assessment 
was also performed with digital photographs and a pigment 
. “good improvement” on average with improvement rate 
of 50–74%. The pigment imaging technology system also 
confirmed the improvement of the pigmentation level on all 
three locations of the face. None of the 50 patients showed any 
signs of severe side effects during the course of the treatment. 

1. A–C 45-year-old patient (A – front; B – left side; C – right side). Left: Before laser treatment; right: after laser treatment (photographed in general light). After 15 weekly treatments, both patients and investigators graded the treatment outcome as “excellent improvement”.

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